Gammapathies monoclonales
De médecine.top
Caractéristiques communes
Neuropathies associated with monoclonal proteins occur in monoclonal gammopathy of undetermined significance, multiple myeloma, Waldenström macroglobulinemia, amyloidosis, and other hematologic malignancies.
MGUS
Hémopathies malignes
IgG: myélome-plasmocytome
IgM: syndrome lymphoprolifératif (lymphome malin)
- Leucémie lymphoïde chronique
- Maladie de Waldenström (lymphome lymphoplasmocytaire)
Amyloïdose
- Souvent lambda
POEMS
(polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes)
- Souvent IgG/IgA et lambda
- POEMS syndrome is characterized by the presence of a monoclonal plasma cell disorder, peripheral neuropathy, and one or more of the following: osteosclerotic myeloma, Castleman disease (angiofollicular lymph node hyperplasia), elevated serum vascular endothelial growth factor, organomegaly, endocrinopathy, edema, typical skin changes, and papilledema.