Différences entre versions de « Insuffisance médullaire »
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| Ligne 8 : | Ligne 8 : | ||
== Aplasie érythrocytaire pure == | == Aplasie érythrocytaire pure == | ||
| + | * Etiologies: parvovirus B19, thymome, auto-immunité, etc... | ||
| + | * A bone marrow biopsy specimen showing a selective decrease in erythrocyte precursors is required to diagnose idiopathic pure red cell aplasia, which is then treated with immunosuppressive medications. | ||
[[Category:Hématologie]] | [[Category:Hématologie]] | ||
[[Category:Oncologie]] | [[Category:Oncologie]] | ||
Version du 17 mai 2020 à 15:41
Anémie aplastique
- Most AA is felt to be related to autoimmunity against stem cells.
- Origine médicamenteuse: traitement anti-thyroïdien (méthimazole et propylthiouracil), β-lactames, sulfonamides, AINS, anticonvulsants, or.
- Traitement:
- Patient < 50 ans avec donneur compatible = allogreffe de cellules souches hématopoïétiques
- Patient > 50 ans ou < 50 ans sans donneur compatible = AA is treated by immunosuppression with antithymocyte globulin, cyclosporine, and prednisone
- Complication: hémoglobinurie paroxystique nocturne chez patients qui développent le clone correspondant
Aplasie érythrocytaire pure
- Etiologies: parvovirus B19, thymome, auto-immunité, etc...
- A bone marrow biopsy specimen showing a selective decrease in erythrocyte precursors is required to diagnose idiopathic pure red cell aplasia, which is then treated with immunosuppressive medications.
